It is known since olden days the use of plants for medicinal purpose. More investigations must be carried out to evaluate the exact mechanism of action of medicinal plants with antidiabetic and insulino mimetic activity. Review of antidiabetic activity of rang jeud thunbergia. Antidiabetic, taraxacum officinale, invitro, alphaamylase, alphaglucosidase 1. Nigerian indigenous antidiabetic medicinal plants are designed and. Shamim hossain, naim hassan, biplab kumar dash, md. Different extracts from medicinal plants have also been used traditionally to. These medicinal plants have been used in traditional systems of indian medicine for treatment of various types of diseases and disorders. The medicinal plants produce antidiabetic activity due to presence of tannin, saponins, alkaloid, glycoside, polyphenol and flavonoids etc. The aim of this study was to investigate the antidiabetic activity and.
Antidiabetic activity and phytochemical screening of extracts. Medicinal plants with potential antidiabetic activity and their assessment. Basotho ethnobotanically reported plants with antidiabetic potentials 3. Phytochemical analysis, antioxidant activity, dpph assay, radical scavenging activity, antidiabetic assay, alpha amylase assay, pavonia procumbens. Evidence based antidiabetic selected indigenous medicinal. Olorunniji, 5 and mohamed eddouks 6 1 phytomedicine, toxicology and reproductive biochemistry research laboratory, department of biochemistry, university of ilorin, ilorin 240003, nigeria. Flavonebased novel antidiabetic and antidyslipidemic agents.
Bnouham m, ziyyat a, mekhfi h, tahri a, legssyer a. Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. The goal of the current study is appreciated various plants, fruits, vegetables used for antidiabetic activity. Studies using both in vitro and in vivo models are necessary to evaluate various medicinal plants species, used in folk medicine, by using scientific criteria. Anti diabetic medicinal plants used for diabetes mellitus maryam rahimi department of horticultural science, university of zabol, iran abstract diabetes mellitus is a group of metabolic diseases characterized by high blood sugar glucose levels, that result from defects in insulin secretion, or action, or both. Mostly, this plant found europe and the northern usa forest 15,16. Chemically synthesized drugs used to decrease the ill effects of dm and its secondary complications cause adverse side effects, viz. Antioxidant and antidiabetic potential of myrothamnus. Overview of antidiabetic medicinal plants longdom publishing sl. Antidiabetic activity and phytochemical screening of extracts of the. Evaluation of antioxidant, antidiabetic and antiobesity. Hypoglycemic activity medicinal plants and their derivatives represent more than 50% of all the drugs in modern therapeutics pan et al.
Plants have been the primary source of drugs and many of the currently available drugs have been directly or indirectly derived from plants. The hypoglycemic activity of a large number of plant products have been evaluated and confirmed in animal models 10 as well as in human beings 14,15. Potential antidiabetic activity of medicinal plants the journal of. An update 1mohd iqbal yatoo, 2archana saxena, 3arumugam gopalakrishnan, 4mahmoud alagawany and 5kuldeep dhama 1sherekashmir university of agricultural sciences and technology of kashmir, shalimar, 190025 srinagar. Antiobesogenic and antidiabetic effects of plants and. Open access international journal of pharmacology issn 18117775 doi. In south africa, the number of people suffering from diabetes is believed to be rising steadily and the current antidiabetic therapies are frequently reported to have adverse side effects. Several drugs such as biguanides and sulfonylureas are presently available to reduce hyperglycemia. Medicinal plants with potential antidiabetic activity and their assessment abdel nasser singab, fadia s youssef and mohamed l ashour department of pharmacognosy, faculty of pharmacy, ain shams university, abbassia, cairo, egypt.
Diabetes mellitus is the most conventional diseases in the world. Despite a noticeable progress in the treatment of diabetes mellitus by synthetic drugs, the search for new natural antidiabetic agents is going on. Diabetes mellitus, medicinal plants, antidiabetic, hypoglycemic, antihyperglycemic. Hypoglycaemic activity of different extracts of various herbal plants. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocininduced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity. Pdf antidiabetic activity of plants, fruits and vegetables. The efficiency of these medicinal plants may regulate the diabetic metabolic. Metformin, for example, is an oral hypoglycemic agent isolated from medicinal plant galega officinalis that was used historically in medieval europe for the treatment of diabetes 11,12.
The use of medicinal plants to manage diabetes is a prelude to a more realistic and more inclusive global health order. In vivo antidiabetic activity of the aqueous leaf extract of croton. Bepls vol 4 2 january 2015 170 page 2015 aels, india. Antidiabetic activity of zingiber officinale in streptozotocininduced type i diabetic rats. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. The present study revealed that aqueous extract exhibited significant in vitro antidiabetic activity. Evaluating medicinal plants for desirable bioactivity goes handinhand with methods in analytical biochemistry for separating and identifying lead compounds. The bioactive compounds of medicinal plants are used as anti diabetic, chemotherapeutic, anti inflammatory, anti arthritic agents where no satisfactory cure is present in modern medicines tanko et al. An overview on antidiabetic medicinal plants having insulin. Undoubtedly, medicinal plants will increasingly become part of the antidiabetic drug mix. This study aims at determining the anidiabetic potential of five traditional medicinal plants such as, sarcostemma brevistigma, grewia hirsuta, indigofera aspalathoides, memecylon edule and solanum trilobatum.
Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in nondiabetic subjects and the same result was seen in diabetic subjects. Isolated compounds from natural products with potential. Antidiabetic medicinal plants gymnema sylvestre gymnema sylvestre has long been used as a treatment for diabetes 11. Diabetes mellitus can be managed by diet, physical exercise, and modern drugs insulin andor oral hypoglycemic drugs such as sulfonylureas and biguanides 5.
Medicinal plants, diabetes mellitus, antidiabetic activity cite this article. Antidiabetic activity different extracts of mf were investigated for antidiabetic activity. Approach to phytochemistry and mechaniasm of action of plants. Here we studied the antidiabetic activity of some medicinal plants mentioned in the unani formulation qurs ziabitus hakim, 1997 hakim ms 1997. Ashrafuzzaman sapon, monokesh kumer sen abstract in the last few years, there has been an exponential growth in the field of herbal medicine and gaining.
Medicinal plants have been suggested since ancient times to be a good source of drugs for treating diabetes. A number of active components were isolated from medicinal plants for direct use as drugs, or act as a lead compound or pharmacological agents. Role of medicinal plants in the management of diabetes. Bhavani 1pg and research department of biochemistry, adhiparasakthi college of arts and science, kalavai 632506, vellore district, tn, india article info abstract article history. It is commonly called wilde roosmaryn, kapokbos meaning snowbush in afrikaans, and wild rosemary eng. Journal of acute disease 20196200 contents lists available at sciencedirect journal of acute disease journal homepage. Determination of in vitro antidiabetic effects of zingiber officinale roscoe 603 glucose diffusion inhibition the potential of ginger rhizome extracts to inhibit glucose diffusion into the external solution was investi gated at set time intervals gallagher et al. Antidiabetic activity medicinal plant aegle marmelos. In vitro antidiabetic activity and mechanism of action of. Antidiabetic and antiinflammatory effects of medicinal. Medicinal plants with potential antidiabetic activity a. Antidiabetic activity and phytochemical screening of. Evaluation of in vitro anti diabetic activity of selected. Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing.
Approach to phytochemistry and mechaniasm of action of. Antidiabetic medicinal plants used by the basotho tribe of. Medicinal plants as an alternative source of antidiabetic agents. In vitro antiglycation activity of some medicinal plants used in diabetes mellitus. Anti diabetic medicinal plants open access journals. Studies on antidiabetic activity of indian medicinal plants using amylase and glucosidase inhibitory activity a pathway to antidiabetic drugs 1,2r. Though diabetes is a global problem so the present study aims to open new avenue to explore the antidiabetic activity of various medicinal plants on a firm scientific footing and different market formulation which add value as novel antidiabetic drug. Plant species with antidiabetic properties plant based medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001. Diabetes mellitus is one of the most common noncommunicable diseases globally.
It is quite a remarkable effort to isolate active components of indian medicinal plants with confirmed hypoglycemic activity as leads, to explain their pharmacological mechanism, and lastly, to develop conventional dosage forms which not only controls diabetes but takes care of associated complications 70, 71. Antidiabetic activity of indian medicinal plants springerlink. Potential antidiabetic activity of medicinal plants a. Antidiabetic potential of two medicinal plants used in. Medicinal plants produce a wide variety of phytochemicals, include alkaloids, phenolic acids, flavonoids, glycosides, saponins, polysaccharides, stilbenes, and tannin, which are intensively investigated for their antidiabetic effects. A majority of the plant species was tested for antidiabetic activity. Antidiabetic potential of medicinal plants and their active components. This has caused an increase in the number of experimental and clinical investigations directed toward the validation of the antidiabetic properties, which are empirically attributed to these remedies 5. Medicinal plants are widely used by majority of populations to cure various diseases and illness and high impact on the worlds economy43. Review article antidiabetic activity of medicinal plants.
Pdf antidiabetic effect of compounds isolated from plants. Plants remain as an important source of therapeutic material for maintaining human health with a broad diversity, and they have improved the quality of human life through disease prevention and treatment for centuries. In the african region this rate is the highest, with 20 million diagnosed diabetics. In vitro and in vivo antidiabetic effect of extracts of. India is the largest producer of medicinal plants and is. Determination of in vitro antidiabetic effects of zingiber. India alone has more than 45,000 plants known to be as medicinal plants used for treatment of various disorders 1,3,2126. The optical enantiomers 70a, 70b, 90a, and 90b of two congeners 70 and 90 exhibiting consistent antidiabetic and antidyslipidemic activities were also prepared. Antidiabetic agents from medicinal plants bentham science. Sep 16, 2016 the prevalence of obesity is increasing worldwide as a result of highcalorie diets and sedentary lifestyles. Review on antidiabetic activity on medicinal plants. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of. Eriocephalus punctulatus is a flowering plant belonging to the asteraceae daisy genus family with over 35 species.
Introduction the plants have been used as a natural cure for several ailments and diseases and are one of the. Pdf in the last few years, there has been an exponential growth in the field of herbal. Review on antidiabetic activity on medicinal plants scholar. Ramasamy1 1indian systems of medicine and natural products laboratory, division of life science, anna university. It assists the researchers to understand mechanism of action, structure and potential antidiabetic activities of scientific evaluated plants. The aim of this study was to evaluate the antidiabetic potential of these two medicinal plants traditionally used in gabon. Plants and their products are being used as a traditional medicine for treating diabetes by up to 90% of the population in developing countries, according to the world health organization who. Searches using medlinepubmed and scopus databases were conducted to find articles in english on compounds isolated from plant species that have been tested using in vivo andor in vitro diabetes models. Antidiabetic activity medicinal plant aegle marmelos linn. Humans have been using plants as a rich source of drugs since ancient times for the management of chronic diseases such as diabetes. Abstract aim of the present study is evaluated various medicinal plants used for antidiabetic activity.
Diabetes mellitus and natures pharmacy of putative. Medicinal plants have always been considered as healthy source of life for all peoples due to its rich therapeutic properties and being 100% natural. The aims of this thesis were to identify the antidiabetic effects and to understand further the mechanisms involved for two traditional plants, borapetol b c1 isolated from tinospora crispa, and gynostemma pentaphyllum gp, in diabetic rats. Current antiobesogenic therapies have limited effectiveness andor severe adverse effects. The presence of one or more compounds in the plant extract may involve in decreasing the blood glucose suggesting that the natural constituents could have act separately or synergistically to induce the hypoglycemic effect. Medicinal plants with antidiabetic activity saponins saponins are secondary metabolites amphipathic glycosides which manufactured by many different plant species, characterized by having high molecular weight, consisting of a sugar moiety or moieties united to. If there is a longterm remedy for diabetes, it must lie in natures pharmacy of putative antidiabetic agents from plants. Plants have been a good source of medicine for the treatment of various type of disease, still many plants and active compounds obtained from plants have not been well characterized. At a dose of 800 mgkg, the plant extract causes 30. Ethnomedicinal plant use has shown promise for the development of cheaper, costeffective antidiabetic agents with fewer side effects. Frontiers evaluation of antioxidant, antidiabetic and. Ajuga remota, antidiabetic activity, blood glucose level, diabetes mellitus.
Many plants have shown their immense potential to fight against dreadful diseases including cancer. Among them, about 400 plants are known to possess varying degree of antihyperglycemic or hypoglycemic activity. Anti diabetic medicinal plants used for diabetes mellitus g arumugam1, p manjula2, n paari2 1 2 doi. Introduction medicinal plants have a long history of use in the treatment of many diseases in human since many decades. When gymnema leaf extract is administered to a diabetic patient, there is stimulation of the pancreas by virtue of which there is an increase in insulin release 14. The bilberry has several medicinal values for the treatment of various ailments including fever, cough, diabetic and liver disorder.
Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. Studies on antidiabetic activity of indian medicinal plants. Asteraceae were taken to evaluate antidiabetic activity. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Inadequate regulation of the blood sugar imposes serious consequences for health. Evaluation of the antidiabetic property of aqueous leaves. Mohamed b, abderrahim z, hassane m, abdelhafid t, abdelkhaleq l. The hybrid congeners 6290 of 6 and 7hydroxyflavones with aminopropanol have been synthesized and evaluated for their antidiabetic activity in sucrosechallenged lowdosed streptozotocin stzinduced diabetic rats and dbdb mice. Antidiabetic potential of medicinal plants and their active. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Jung m, park m, lee hc, kang y, kang es and kim sk.
Diabetes is a complex and multifarious group of disorders characterized by hyperglycemia that has reached epidemic proportions in the present century. Given the large number of plants reputed to possess antidiabetic properties saraswat et al. Oct 11, 2017 diabetes mellitus dm is one of the major health problems in the world, especially amongst the urban population. Medicinal plants have been proposed as rich yet unexploited potential sources for. Phytochemical potential of pavonia procumbens wall. However, there are still not many data available about the hypoglycemic activity of this medicinal plant, t. Antidiabetic potential of medicinal plants and their. The scientific articles evidenced that the fruit has antidiabetic and hypoglycemic activity 17.
When gymnema leaf extract is administered to a diabetic patient, there is stimulation of the pancreas by. The antidiabetic activity performed in plant is often due to the presence of phenolic acids, phenolic diterpenes, flavonoids, steroids, triterpenoids, alkaloids and other nitrogen compounds perez. Introduction now a days medicinal plants are considered as an important therapeutic aid for reducing ailments of human being. Natural products, particularly of plant origin, are the main quarry for discovering promising lead candidates and play an imperative role in the upcoming drug development programs 24,25,26.
The selected plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using. It is the fourth leading causes of death in the most developed countries and there in substantial evendiced that it in epidemic in many developing and newly industrialized nations. Among the different parts of the plant, the stem showed highest activity fallowed by roots and least activity furnished by flowers of plant. Medicinal plants used in the management of diabetes mellitus 2015 musa t. Medicinal plants with antidiabetic activity saponins saponins are secondary metabolites amphipathic glycosides which manufactured by many different plant species, characterized by having high molecular weight, consisting of a sugar moiety or moieties united to a triterpenoid c30 or steroid c27 sapogenins43. In vitro investigation of antidiabetic potential of selected. Medicinal plants used in the management of diabetes mellitus 2015.
Strong medicinal systems like ayurveda, unani and chinese, are still promising and has been practised over 1500 years. Promising antidiabetic drugs, medicinal plants and herbs. In vitro antidiabetic activities and gcms phytochemical. Systematic studies on the folklore medicinal plants that combat diabetes mellitus are.
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